产品货号：
Z12019
中文名称：
AURKB抗体
英文名称：
Anti-AURKB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AURKB Antibody |
| 指标别名 | aurora kinase B;AIK2;AIM-1;AIM1;ARK-2;ARK2;AurB;IPL1;PPP1R48;STK-1;STK12;STK5;aurkb-sv1;aurkb-sv2;AURKB |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB |
| 基因名称 | AURKB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of mouse Aurora B(72-87aa QNKQPFTIDNFEIGRP),different from the related rat sequence by two anino acids. |
| 实际分子量 | 39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | AURKB(aurora kinase B) also called Aik2,AIM-1,ARK2,AurB,STK12,IPL1,PPP1R48 or STK5,localizes to microtubules near kinetochores,specifically to the specialized microtubules called K-fibers.Cell cycle and Northern blot analyses showed that STK12 is expressed in the S phase and persistently thereafter.Western blot analysis indicated that STK12 is localized in the midbodies during anaphase.Northern blot analysis detected strong expression of a 1.5-kb STK12 transcript in thymus,with weaker expression in small intestine,testis,colon,spleen,and brain.The AURKB gene is mapped on 17p13.1.Examination of the role of both kinases in the phosphorylation of CENPA revealed that the reaction is mediated sequentially by AURKA and AURKB in early mitosis.EB1 overexpression enhanced AURKB kinase activity,and knockdown of EB1 with small interfering RNA impaired AURKB activity.EB1 protected AURKB from dephosphorylation/inactivation by protein phosphatase-2A by blocking binding of PP2A to AURKB. |
| Uniprot ID | O70126 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | aurora kinase B |
| 蛋白名全称 | Aurora kinase B |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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